New mesothelioma treatments have been studied and enhanced with the expectation of finding more effective treatments a that - in best case - can provide a cure. Mesothelioma researchers are in agreement that new mesothelioma treatment approaches will sooner or later be proven as successful, despite the fact that they have yet to show conclusive results that are better than traditional methods. New approaches to treat malignant mesothelioma are currently being tested and some of these are:

- Anti-angiogenesis - a therapy using drugs or other substances to stop tumors from creating new blood vessels, thus, preventing the development of the tumor.  Anti-angiogenesis drugs do not straightly hit cancer cells. However, it targets the blood supply essential for survival and growth of the tumor. Thus, they can avoid new tumors from existing, and cause tumors to shrink.

- Photodynamic therapy (PDT) - highly specialized and specific form of treatment used to pleural mesothelioma. On the other hand, this treatment is generally inapt for patients with metastasized cancer compared to patients who have localized disease. This type of therapy involves the utilization of light energy to destroy cancer cells. 

- Immunotherapy – also called biological therapy which uses the body's own immune system to guard itself against disease. Researchers have discovered that the immune system has the capacity to distinguish the difference between healthy cells and cancer cells and able to eliminate those turn out to be cancerous. This is designed to restore and enhance the immune system's natural anticancer function. There are two main types of immunotherapy:

1. Active immunotherapy- the process of removing cancer cells from a patient and then treated in a laboratory to develop them into a vaccine to be injected to the patient. If the treatment is successful, the patient's immune system recognizes the vaccine as a dangerous substance, thus recognizing the cancer as detrimental as well.

2. Passive immunotherapy – the procedure of utilizing substances such as cytokines and other agents to assist in  the improvement the patient's immune reaction to their cancer.
- Gene therapy - involves using genetic substance to distinctively target cancer cells and make them more susceptible to chemotherapy treatment. The major type of gene therapy being enhanced for use in mesothelioma patients is called "suicide gene therapy," This type of therapy forces cancer cells to create substances that cause it death. While going through this type of gene therapy, the patient is treated with a non-infectious disease that has been distorted with genetic elements which produces a particular protein. With this method, the patient is then treated with a chemotherapeutic prescription that is specifically formulated to be toxic only to cancer cells. This type of therapy has resulted to a number of promising new mesothelioma treatment outcomes for mesothelioma patients, nevertheless it is still only offered through clinical trials.